The use of rheology to elucidate the granulation mechanisms of a miscible and immiscible system during continuous twin-screw melt granulation

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• 作者：Tinne Monteyne^a ; ^{Tinne.Monteyne@UGent.be" class="auth_mail" title="E-mail the corresponding author} ; Liza Heeze^a ; ^{Liza.Heeze@UGent.be" class="auth_mail" title="E-mail the corresponding author} ; Sé ; verine Thé ; rè ; se F.C. Mortier^a ; ^c ; ^{Severine.Mortier@UGent.be" class="auth_mail" title="E-mail the corresponding author} ; Klaus Oldö ; rp^d ; ^{Klaus.Oldoerp@Thermofisher.com" class="auth_mail" title="E-mail the corresponding author} ; Ingmar Nopens^c ; ^{Ingmar.Nopens@UGent.be" class="auth_mail" title="E-mail the corresponding author} ; Jean-Paul Remon^a ; ^{JeanPaul.Remon@UGent.be" class="auth_mail" title="E-mail the corresponding author} ; Chris Vervaet^b ; ^{Chris.Vervaet@UGent.be" class="auth_mail" title="E-mail the corresponding author} ; Thomas De Beer^b ; ^{Thomas.Debeer@Ugent.be" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Tan(δ) ; Agglomeration mechanism ; Spectroscopy ; Miscibility ; Drug&ndash ; binder interactions
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：20 August 2016
• 年：2016
• 卷：510
• 期：1
• 页码：271-284
• 全文大小：1639 K

文摘

Twin-screw hot melt granulation (TS HMG) is a valuable, but still unexplored alternative to granulate temperature and moisture sensitive drugs in a continuous way. Recently, the material behavior of an immiscible drug–binder blend during TS HMG was unraveled by using a rheometer and differential scanning calorimetry (DSC). Additionally, vibrational spectroscopic techniques proved the link between TS HMG and rheology since equal interactions at molecular level did occur in both processes. This allowed to use a rheometer to gain knowledge of the material behavior during hot melt processing of an immiscible drug–binder blend. However, miscibility of a drug–binder formulation and drug–binder interactions appear to influence the rheological properties and, hence conceivably also the granulation mechanism. The aim of this research was to examine if the TS HMG process of a miscible formulation system is comparable with the mechanism of an immiscible system and to evaluate whether rheology still serves as a useful tool to understand and optimize the hot melt granulation (HMG) process. The executed research (thermal analysis, rheological parameters and spectroscopic data) demonstrated the occurrence of a high and broad tan(δ) curve without a loss peak during the rheological temperature ramp which implies a higher material deformability without movement of the softened single polymer chains. Spectroscopic analysis revealed drug–polymer interactions which constrain the polymer to flow independently. As a result, the binder distribution step, which generally follows the immersion step, was hindered. This insight assisted the understanding of the granule properties. Inhomogeneous granules were produced due to large initial nuclei or adhesion of multiple smaller nuclei. Consequently, a higher granulation temperature was required in order to get the binder more homogeneously distributed within the granules.