The atrial natriuretic peptide (ANP) knockout mouse does not exhibit the phenotypic features of pre-eclampsia or demonstrate fetal growth restriction
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- 作者：Sarah L. Finn-Sell ; sarah.finn-sell@manchester.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Lewis J. Renshall ; Elizabeth J. Cowley ; Mark R. Dilworth ; Mark Wareing ; Susan L. Greenwood ; Colin P. Sibley ; Elizabeth C. Cottrell
- 关键词：Pre-eclampsia ; Fetal growth restriction ; Atrial natriuretic peptide ; Mouse
- 刊名：Placenta
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：25-27
- 全文大小：286 K
文摘
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Mouse models of pre-eclampsia and fetal growth restriction are needed to test potential therapies.
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ANP knockout mice have previously been identified as a potential model of pre-eclampsia.
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We find that these mice do not exhibit pregnancy-associated hypertension, or fetal growth restriction.
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ANP knockout mice do not provide a robust model of pre-eclampsia or fetal growth restriction.