CENP-A Modifications on Ser68 and Lys124 Are Dispensable for Establishment, Maintenance, and Long-Term Function of Human Centromeres

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• 作者：Daniele Fachinetti¹ ; ⁴ ; ⁵ ; Glennis A. Logsdon² ; ³ ; ⁴ ; Amira Abdullah¹ ; Evan B. Selzer² ; Don W. Cleveland¹ ; ^{dcleveland@ucsd.edu} ; Ben E. Black² ; ³ ; ⁶ ; ^{blackbe@mail.med.upenn.edu}
• 关键词：centromere ; CENP-A ; epigenetics ; chromatin assembly ; histone variants ; mitosis ; kinetochore ; histone ; CRISPR ; auxin
• 刊名：Developmental Cell
• 出版年：2017
• 出版时间：9 January 2017
• 年：2017
• 卷：40
• 期：1
• 页码：104-113
• 全文大小：2444 K
• 卷排序：40

文摘

CENP-A gene replacement demonstrates that Ser68phos and Lys124ub are dispensable Ser68phos and Lys124ub are not required to maintain centromeres indefinitely CENP-A without Ser68phos or Lys124ub mediates centromeric chromatin assembly in G1 Ser68phos and Lys124ub are dispensable for early steps in centromere establishment