Uptake of Marasmius oreades agglutinin disrupts integrin-dependent cell adhesion
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- 作者：Samuel Juillota ; b ; c ; Catherine Cotta ; c ; Josef Madla ; c ; Julie Claudinona ; c ; Niels Sebastiaan Johannes van der Veldend ; Markus Kü ; nzlerd ; Roland Thuenauera ; c ; Winfried Rö ; mera ; b ; c ; winfried.roemer@bioss.uni-freiburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：MOA ; Marasmius oreades agglutinin ; MDCKII ; Madin&ndash ; Darby canine kidney strain II ; FAK ; Focal adhesion kinase ; BAX ; BCL-2-associated X protein ; HUS ; Hemolytic uremic syndrome ; CME ; Clathrin-mediated endocytosis ; GSLs ; Glycosphingolipids ; DMEM ; Dulbecco's Modified Eagle Medium ; FCS ; Fetal calf serum ; PMP ; D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol ; StxB ; Shiga toxin B-subunit ; wt ; Wild-type ; FACS ; Fluorescence-activated cell sorting ; PBS ; Phosphate buffered saline ; PNPG ; 4-Nitro
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1860
- 期：2
- 页码：392-401
- 全文大小：2943 K
文摘
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We studied MOA toxicity in MDCKII cells.
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MOA disturbs integrin-dependent cell adhesion signaling.
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Toxicity of the lectin is both binding- and protease-dependent.
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MOA accumulates in late endosomal compartments.