Epigenetic regulation of redox signaling in diabetic retinopathy: Role of Nrf2
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- 作者：Renu A. Kowluru ; rkowluru@med.wayne.edu ; Manish Mishra
- 关键词：AGEs ; advanced glycation end products ; ARE ; antioxidant response element ; ATP ; adenosine triphosphate ; 5mC ; 5-methyl cytosine ; CBP ; CREB-binding protein ; p300 ; E1A binding protein P300 ; Dnmts ; DNA methyl transferases ; ETC ; electron transport complex ; FAD ; flavin adenine dinucleotide ; GCLC ; glutamate-L-cysteine ligase ; catalytic subunit ; GSH ; glutathione ; GSSG ; oxidized glutathione ; H3K4 ; histone H3 lysine 4 ; H3K4me1 ; mono-methyl H3K4 ; H3K4me2 ; di-methyl H3K4 ; H3K4me3 ; tri-methyl H3K4 ; H3K9 ; hist
- 刊名：Free Radical Biology and Medicine
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：103
- 期：Complete
- 页码：155-164
- 全文大小：837 K
- 卷排序：103
文摘
Diabetes-induced metabolic abnormalities increase cellular oxidative stress. Oxidative stress alters the epigenetic machinery. Epigenetics affects Nrf2-mediated signaling, altering mitochondrial homeostasis. Damaged mitochondria accelerates apoptosis, resulting in diabetic retinopathy.