Synthesis, characterization, in vitro cytotoxicity and anticancer effects of ruthenium(II) complexes on BEL-7402 cells
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- 作者：Cheng Zhang1 ; Bing-Jie Han1 ; Chuan-Chuan Zeng ; Shang-Hai Lai ; Wei Li ; Bing Tang ; Dan Wan ; Guang-Bin Jiang ; Yun-Jun Liu ; lyjche@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ruthenium(II) polypyridyl complexes ; Cytotoxicity in vitro ; Reactive oxygen species ; Mitochondrial membrane potential ; Western blot analysis
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：157
- 期：Complete
- 页码：62-72
- 全文大小：2883 K
文摘
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Four new ruthenium(II) complexes were synthesized and characterized.
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The cytotoxicity of the complexes against five cancer cell lines was investigated.
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The apoptosis, comet assay, cell migration and cellular uptake were investigated.
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The cell cycle arrest was investigated by flow cytometry.
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The expression of Bcl-2 family proteins was assayed by western blot analysis.