Protein binding and anticancer activity studies of ruthenium(II) polypyridyl complexes toward BEL-7402 cells
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- 作者：Shang-Hai Laia ; Wei Lia ; Jun-Hua Yaob ; Bing-Jie Hana ; Guang-Bin Jianga ; Cheng Zhanga ; Chuan-Chuan Zenga ; Yun-Jun Liua ; lyjche@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ru (II) polypyridyl complexes ; Cytotoxicity in vitro ; Reactive oxygen species ; Mitochondrial membrane potential ; Western blot analysis
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：158
- 期：Complete
- 页码：39-48
- 全文大小：2581 K
文摘
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Four new ruthenium(II) complexes were synthesized and characterized.
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Cytotoxicity of complexes toward HepG-2, HeLa, MG-63, A549, BEL-7402 was studied.
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The apoptosis, comet assay, cellular uptake, ROS, cell cycle arrest were studied.
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The expression of Bcl-2 family proteins was assayed by western blot analysis.
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The protein-binding of the complexes with BSA was investigated.