Simple Brønsted acid catalyzed C-H functionalization: efficient access to poly-substituted pyridines
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- 作者：Shujun Laia ; Xuwen Rena ; Jinzhong Zhaoa ; zhaojz@sxau.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhuo Tangb ; tangzhuo@cib.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Guangxun Lib ; ligx@cib.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Hantzsch 1 ; 4-dihydropyridine ; C&ndash ; H functionalization ; Imine ; Poly-substituted pyridine
- 刊名：Tetrahedron Letters
- 出版年：2016
- 出版时间：6 July 2016
- 年：2016
- 卷：57
- 期：27-28
- 页码：2957-2961
- 全文大小：819 K
文摘
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Benzylic C–H bond of pyridines were functionalized with ordinary aromatic imines.
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Simple Brønsted acids efficiently catalyzed the reactions.
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Poly-substituted pyridines were obtained from accessible aromatic Hantzsch esters.