The Lumipulse G HBsAg-Quant assay for screening and quantification of the hepatitis B surface antigen
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- 作者：Ruifeng Yang1 ; yangruifeng103@163.com" class="auth_mail" title="E-mail the corresponding author ; Guangjun Song2 ; sguangjun2013@163.com" class="auth_mail" title="E-mail the corresponding author ; Wenli Guan3 ; 1282071984@qq.com" class="auth_mail" title="E-mail the corresponding author ; Qian Wang3 ; 1520219971@qq.com" class="auth_mail" title="E-mail the corresponding author ; Yan Liu3 ; helen_yan320@sohu.com" class="auth_mail" title="E-mail the corresponding author ; Lai Wei ; weilai@pkuph.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：HBV ; hepatitis B virus ; HBsAg ; hepatitis B surface antigen ; HBeAg ; hepatitis B e antigen ; anti-HBc ; antibodies against hepatitis B core antigen ; anti-HBs ; antibodies against hepatitis B surface antigen ; NAT ; nucleic acid testing ; CHB ; chronic hepatitis B ; HCC ; hepatocellular carcinoma ; OBI ; occult HBV infection ; PEG-IFN ; peginterferon ; NA ; nucleos(t)ide analogue ; ETV ; entecavir ; cccDNA ; covalently closed circular DNA ; CV ; coefficient of variation
- 刊名：Journal of Virological Methods
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：228
- 期：Complete
- 页码：39-47
- 全文大小：1523 K
文摘
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The Lumipulse HBsAg assay showed a detection limit of 0.005 IU/mL.
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The assay identified 1% more clinical samples with trace amount of HBsAg.
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The Lumipulse assay showed high correlation (R2 ≥ 0.97, P < 0.01) with the Architect and Elecsys assays in quantifying HBsAg.
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The Lumipulse assay yielded similar patterns of HBsAg fluctuation when used for the treatment monitoring as compared to the Architect and Elecsys assays.
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HBsAg measured by the Lumipulse assay was slightly lower than that by the Architect (0.19 log10 IU/mL) and Elecsys assay (0.07 log10 IU/mL).