pH-responsive copolymers based on pluronic P123-poly(β-amino ester): Synthesis, characterization and application of copolymer micelles
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- 作者：Xiaoqing Caia ; Mengrui Liua ; Chen Zhangb ; Deqing Sunc ; d ; sundq0405@126.com" class="auth_mail" title="E-mail the corresponding author ; Guangxi Zhaia ; professorgxzhai@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：pH-sensitive ; Self-assembled micelles ; Poly(β-amino ester) ; Curcumin ; Cancer therapy
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：142
- 期：Complete
- 页码：114-122
- 全文大小：2285 K
文摘
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A novel pH-responsive copolymer micelles based on Pluronic P123-poly(β-amino ester) (P123-PAE) were firstly synthesized and designed.
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The micelle solution showed obvious changes in particle size and zeta potential with the variation of pH value.
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The pH-dependent drug release, cell cytotoxicity and uptake of micelles can be observed from the studies.
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The P123-PAE micelles can significantly prolong the retention time of Cur in vivo.