Involvement of Heme Oxygenase-1 in particulate matter-induced impairment of NO-dependent relaxation in rat intralobar pulmonary arteries
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- 作者：Marjorie Barriera ; b ; 1 ; Marc-Antoine Bé ; gorrea ; b ; 1 ; Isabelle Baudrimonta ; b ; Mathilde Duboisa ; b ; Vé ; ronique Freund-Michela ; b ; Roger Marthana ; b ; c ; Jean-Pierre Savineaua ; b ; Bernard Mullera ; b ; Arnaud Courtoisa ; b ; c ; arnaud.courtois@u-bordeaux.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：SRM1648 ; Standard Reference Materials 1648 ; HO-1 ; Heme Oxygenase-1 ; sGC ; soluble Guanylyl Cyclase ; NO ; nitric oxide ; PM ; particulate matter
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：32
- 期：Complete
- 页码：205-211
- 全文大小：479 K
文摘
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Urban particulate matter induced Heme-Oxygenase 1 expression in rat intrapulmonary arteries.
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These pollutants impaired nitric oxide-dependent relaxation in those arteries.
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That alteration was prevented by concomitant exposure to HO-1 inhibitor.
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We highlighted the role of HO-1 in particulate matter-induced detrimental effects in pulmonary circulation.