Soluble guanylyl cyclase-activated cyclic GMP-dependent protein kinase inhibits arterial smooth muscle cell migration independent of VASP-serine 239 phosphorylation
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- 作者：Andrew W. Holta ; Danielle N. Martina ; Patti R. Shaverb ; Shaquria P. Adderleya ; Joshua D. Stonea ; Chintamani N. Joshia ; Jake T. Franciscoa ; Robert M. Lusta ; Douglas A. Weidnerc ; Brian M. Shewchukb ; David A. Tulisa ; tulisd@ecu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BAY 60-2770 ; cGMP ; Migration ; PKG ; Smooth muscle cell ; VASP
- 刊名：Cellular Signalling
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：28
- 期：9
- 页码：1364-1379
- 全文大小：2411 K
文摘
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Heme-independent sGC activation by BAY60 attenuates ASM growth.
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The anti-migratory mechanisms of BAY60 operate in PKG/VASP-dependent manner.
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VASP phosphorylation differentially regulates PKG activity.
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pVASP·S239 is involved yet not responsible for the anti-migratory actions of BAY60.
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BAY60 could serve as a potential pharmacotherapy against pathologic arterial growth.