• 作者：Rafael Gó ; mez Rodrí ; guez^a ; ^{925252585@telefonica.net} ; Antonio Guardiola Ar&eacute ; valo^a ; Ana Zaida Gó ; mez Moreno^a ; Almudena Garcí ; a Vela^a ; C&eacute ; sar Gó ; mez Hernando^b ; Rufo Rodrí ; guez Merlo^c ; Juan Jos&eacute ; Sá ; nchez Ruano^a ; Gema de la Cruz P&eacute ; rez^a
• 关键词：Virus de la hepatitis B ; Infecció ; n cró ; nica por virus de la hepatitis B ; Epidemiologí ; a
• 刊名：Gastroenterolog¨ªa y Hepatolog¨ªa
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：36
• 期：4
• 页码：243-253
• 全文大小：629 K

Objective

To determine the clinical, laboratory, serological and histologic characteristics of chronic hepatitis B virus carriers in our environment.

Material and methods

A retrospective cohort study was performed that included chronic AgHBs carriers aged more than 13 years attending our service since January 2000.

Results

A total of 474 patients were included. At diagnosis, 55.49 % were men, with a mean age of 41.05¡À13.93 years. Alanine aminotransferase (ALT) levels were within the normal range in 57.17 % of the patients, and 87.76 % were AgHBe(?). Hepatitis C and D virus coinfection was found in 3.62 % and 1.86 % , respectively. Liver biopsy was performed in 31.22 % ; varying grades of inflammation-fibrosis were found in 63.51 % and cirrhosis was found in 12.84 % . Compared with AgHBe(?) patients, those who were AgHBe(+) were younger and had greater disease activity. This difference was statistically significant. Patients in the immunotolerant phase were the least numerous (5.26 % ), while AgHBe(?) patients with chronic HBV infection were the most numerous (48.32 % ). Patients in the immunoreactive phase showed greater histological involvement (16.67 % cirrhosis). A familial history of chronic HBV was found in 21.52 % . The percentage of non-Spanish patients increased in the last few years and accounted for 18.78 % .

Conclusion

Chronic HBV infection in our environment occurs mainly in middle-aged persons. GPT values are normal in more than 50 % , most are AgHBe(?), and approximately half are inactive carriers. The incidence of chronic infection has increased in the non-Spanish population in recent years.