Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives

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• 作者：Diego G. Ghiano^a ; Agustina de la Iglesia^b ; Nina Liu^c ; Peter J. Tonge^c ; Hé ; ctor R. Morbidoni^d ; ^e ; Guillermo R. Labadie^a ; ^f ; ^{labadie@iquir-conicet.gov.ar}
• 关键词：1 ; 2 ; 3-triazoles ; Tuberculosis ; Resistant strains ; Parallel solution synthesis ; SAR ; ADME-tox
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：842-852
• 全文大小：764 K
• 卷排序：125

文摘

A collection of different 1,2,3-triazolyl fatty acids derivatives were prepared. The most active compounds displayed a M. tuberculosis MIC below 2 μM. Compound 11 had the same MIC towards a set of clinically isolated resistant strains.