The bispecific antibody aimed at the vicious circle of IL-1β and IL-17A, is beneficial for the collagen-induced rheumatoid arthritis of mice through NF-κB signaling pathway
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- 作者：Qiang Wua ; Yunxin Wanga ; Qiuying Wanga ; Dan Yua ; Yuyang Wanga ; Liying Songa ; Zhihang Liua ; Xianlong Yec ; Pengfei Xua ; Hongxue Caoa ; Deshan Lia ; b ; Guiping Rena ; b ; renguiping@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bispecific antibody ; Rheumatoid arthritis (RA) ; IL-1β ; IL-17A ; NF-κB
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：179
- 期：Complete
- 页码：68-79
- 全文大小：3502 K
文摘
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BsAb (anti-IL-1β and anti-IL-17A) had beneficial effects on clinical symptom and histological lesion of CIA mice.
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BsAb had therapeutic effect, superior to Adalimumab and Dexamethasone in the aspect of inflammation cytokines.
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BsAb could suppress NF-κB pathway and ameliorate the vicious circle of IL-1β and IL-17A.
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