Solubility correlation and thermodynamic analysis of two forms of Metaxalone in different pure solvents

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• 作者：Minghuang Hong¹ ; ^{mhhong@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Shiwang Wu¹ ; ^{wushiwangecust@163.com" class="auth_mail" title="E-mail the corresponding author} ; Minghui Qi ^{mhqi@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Guobin Ren ; ^{rgb@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Solubility ; Thermodynamic models ; Endothermic ; Entropy driven ; Nonspontaneous
• 刊名：Fluid Phase Equilibria
• 出版年：2016
• 出版时间：15 February 2016
• 年：2016
• 卷：409
• 期：Complete
• 页码：1-6
• 全文大小：637 K

文摘

The solubility data of two forms of MTX in ethanol, isopropanol, ethyl acetate and toluene was measured over the temperature range from 283.15 K to 323.15 K using shake flask method under atmospheric pressure. The experimental results indicated that the solubility of both forms of MTX increased as the temperature increased. And it was clear that the solubility of form B was lower than the solubility of form A at the same state. The experimental data was correlated by the modified Apelblat equation, the polynomial equation and the Buchowski–Ksiazczak λh equation. All these thermodynamic models gave satisfactory correlation results, with the polynomial equation showing better fitting degree than the other two equations. The results of thermodynamic parameters (△H_d > 0, △S_d > 0, △G_d > 0) indicated an endothermic, entropy driven and nonspontaneous dissolution process of MTX in selected pure solvents.