Striatal silent lacunar infarction is associated with changes to the substantia nigra in patients with early-stage Parkinson’s disease: A diffusion kurtosis imaging study
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- 作者：Guohua Zhanga ; b ; Yuhu Zhanga ; Chengguo Zhangb ; Yukai Wangb ; Guixian Maa ; Kun Niea ; Haiqun Xieb ; Jianping Liub ; Lijuan Wanga ; wljgd68@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Diffusion kurtosis imaging ; Mean kurtosis ; Parkinson&rsquo ; s disease ; Striatal silent lacunar infarction ; Structural changes ; Substantia nigra
- 刊名：Journal of Clinical Neuroscience
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：138-141
- 全文大小：238 K
文摘
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Nearly 50% Parkinson’s disease (PD) patients older than 50 suffered from striatal silent lacunar infarction (SSLI).
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SSLI is associated with changes to the substantia nigra (SN) in PD patients.
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Structural changes to the SN could be detected by diffusion kurtosis imaging.
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Structural changes to the SN become more obvious with an increase in SSLI lesions.
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It was implied that SSLI might aggravate the motor disorder of patients with PD.