A comparative study on the efficiency of chitosan-N-acetylcysteine, chitosan oligosaccharides or carboxymethyl chitosan surface modified nanostructured lipid carrier for ophthalmic delivery of curcumin
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- 作者：Jinyu Lia ; Dandan Liub ; liudandan1124@126.com" class="auth_mail" title="E-mail the corresponding author ; Guoxin Tana ; Zhinan Zhaoa ; Xinggang Yanga ; Weisan Pana ; pppwwwsss@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Curcumin ; Chitosan-N-acetyl-l-cysteine ; Nanostructured lipid carrier ; Chitosan oligosaccharides ; Carboxymethyl chitosan ; Ophthalmic drug delivery
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：146
- 期：Complete
- 页码：435-444
- 全文大小：2838 K
文摘
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A two-step covalent binding between N-acetyl-l-cysteine (NAC) and chitosan (CS) was proposed.
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The ophthalmic delivery of curcumin (CUR) was enhanced by elaborating nanostructured lipid carrier (NLC) decorating with CS derivatives.
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The CS-NAC-CUR-NLC was superior to chitosan oligosaccharides (COS) or carboxymethyl chitosan (CMCS) modification in ophthalmic delivery.
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The superiority in view of: extended release, corneal rention time and permeability through the cornea.
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The CS-NAC coated CUR-NLC induced neither a feeling of discomfort nor irritation.
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