Epigenetics and Early Life Origins of Chronic Noncommunicable Diseases

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• 作者：Guoying Wang ; M.D. ; Ph.D.^a ; Sheila O. Walker ; Ph.D.^a ; ^b ; Xiumei Hong ; M.D. ; Ph.D.^a ; Tami R. Bartell^c ; Xiaobin Wang ; M.D. ; M.P.H. ; Sc.D.^a ; ^c ; ^{Xiwang@jhsph.edu}
• 关键词：Epigenetics ; Chronic disease ; Early life origin ; Obesity ; Mental health ; Addiction
• 刊名：Journal of Adolescent Health
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：52
• 期：2_supp_S2
• 页码：S14-S21
• 全文大小：490 K

文摘

In light of the increasing threats of chronic noncommunicable diseases in developing countries, the growing recognition of the early life origins of chronic disease, and innovative breakthroughs in biomedical research and technology, it is imperative that we harness cutting-edge data to improve health promotion and maintenance. It is well recognized that chronic diseases are complex traits affected by a wide range of environmental and genetic factors; however, the role of epigenetic factors, particularly with regard to early life origins, remains largely unexplored. Given the unique properties of the epigenome¡ªfunctionality during critical time windows, such as the intrauterine period, heritability, and reversibility¡ªenhancing our understanding of epigenetic mechanisms may offer new opportunities for the development of novel early prediction and prevention paradigms. This may present an unparalleled opportunity to offer maternal and child health professionals important tools with the translational value to predict, detect, and prevent disease at an early age, long before its clinical occurrence, and as such, break lifelong and transgenerational cycles of disease. In doing so, modern technology can be leveraged to make great contributions to population health, quality of life, and reducing the burdensome economic costs of noncommunicable diseases in developing countries.