Why depression and pain often coexist and mutually reinforce: Role of the lateral habenula
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- 作者：Jicheng Li ; Yang Li ; Beilin Zhang ; Xiangfeng Shen ; Hua Zhao ; zhua@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：LHb ; lateral habenula ; CUMS ; chronic ; unpredictable mild stress procedure ; PANs ; pain-activated neurons ; 5-HT ; serotonin ; DRN ; dorsal raphe nucleus ; FST ; forced swimming test ; SPT ; sucrose preference test
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：284
- 期：part_PA
- 页码：106-113
- 全文大小：1178 K
文摘
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The firing rates of pain-activated neurons in the LHb of depressed rats were increased
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The percentage of c-Fos positive cells in LHb was significantly increased in rats receiving CUMS and pain stimulation
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Antidepressant suppressed the firing rates of PANs and c-Fos expression by pain stimulation in LHb of depressed rats
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The LHb lesion can improve both depression-like behavior and hyperalgesia in depressed rats with pain sensitivity
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Hyperactivity of the LHb neurons contributes to depression-pain comorbidity in rats