Sexually dimorphic deficits of prepulse inhibition in patients with major depressive disorder and their relationship to symptoms: A large single ethnicity study

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• 作者：Junko Matsuo ; Miho Ota ; Shinsuke Hidese ; Hiroaki Hori ; Toshiya Teraishi ; Ikki Ishida ; Moeko Hiraishi ; Hiroshi Kunugi ; ^{hkunugi@ncnp.go.jp}
• 关键词：Prepulse inhibition ; Major depressive disorder ; Startle reflex ; Habituation ; Symptoms ; Sex difference
• 刊名：Journal of Affective Disorders
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：211
• 期：Complete
• 页码：75-82
• 全文大小：584 K
• 卷排序：211

文摘

Male patients with MDD showed significantly lower PPI than male comparisons. HAM-D total and subscales were negatively correlated with PPI in male patients. PPI in remitted patients was not significantly different from comparisons. PPI deficits and relationship to symptoms were not observed in female patients. The effect of antidepressant medication on PPI was not significant.