Changes in cytokine and chemokine expression distinguish dysthymic disorder from major depression and healthy controls

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• 作者：Pei-Shen Ho^a ; Che-Hung Yen^b ; ^c ; Chun-Yen Chen^b ; ^d ; San-Yuan Huang^b ; ^d ; Chih-Sung Liang^a ; ^b ; ^{lcsyfw@gmail.com}
• 关键词：DSM-5 ; Diagnostic and Statistical Manual of Mental Disorders ; Fifth Edition ; IL ; interleukin ; TNF-α ; tumor necrosis factor alpha ; HADM ; Hamilton Depression Rating Scale ; BMI ; body mass index ; MD ; major depression ; DD ; dysthymic disorder ; HC ; healthy controls ; IL-1RA ; interleukin-1 receptor antagonist ; FGF ; fibroblast growth factor ; G-CSF ; granulocyte colony-stimulating factor ; GM-CSF ; granulocyte-macrophage colony-stimulating factor ; IFN-γ ; interferon gamma ; IP-10 ; interferon gamma-induced prote
• 刊名：Psychiatry Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：248
• 期：Complete
• 页码：20-27
• 全文大小：525 K
• 卷排序：248

文摘

Dysthymia had more widespread differential expression in cytokines and chemokines. Changes in IP-10 and MCP-1α correlated with depression improvement in dysthymia. The levels of IP-10 highly predicted dysthymia. The cytokine network of dysthymia adopted a more hub-like architecture. The interconnections of IL-2 and eotaxin-1 in network increased in dysthymia