Epigenetic Modifiers Facilitate Induction and Pluripotency of Porcine iPSCs

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• 作者：Jian Mao¹ ; Qian Zhang¹ ; Wei Deng¹ ; Hua Wang¹ ; Kai Liu¹ ; Haifeng Fu¹ ; Qiang Zhao¹ ; Xumin Wang² ; Lin Liu¹ ; ^{liulin@nankai.edu.cn}
• 关键词：iPSC ; epigenetics ; reprogramming ; porcine
• 刊名：Stem Cell Reports
• 出版年：2017
• 出版时间：10 January 2017
• 年：2017
• 卷：8
• 期：1
• 页码：11-20
• 全文大小：3963 K
• 卷排序：8

文摘

Epigenetic modifiers facilitate induction and quality of porcine iPSCs Tet1, Tet3, or Kdm3a increases naive pluripotency network in association with Rex1 Unlike cytoplasmic Rex1, nuclear expression of Rex1 is associated with high pluripotency HDAC inhibitors further activate Rex1 and reduce reliance on the exogenous genes