Characterization of NoV P particle-based chimeric protein vaccines developed from two different expression systems

详细信息    查看全文

• 作者：Lu Fu^a ; ^b ; ¹ ; Hao Jin^c ; ¹ ; Yongjiao Yu^a ; ^b ; Bin Yu^a ; ^b ; Haihong Zhang^a ; ^b ; Jiaxin Wu^a ; ^b ; Yuhe Yin^c ; Xianghui Yu^a ; ^b ; Hui Wu^a ; ^b ; ^{topwuhui@jlu.edu.cn} ; Wei Kong^a ; ^b ; ^{weikong@jlu.edu.cn}
• 关键词：P particle ; Soluble expression system ; Inclusion body expression system ; Yield ; Polymer form ; Immunogenicity
• 刊名：Protein Expression and Purification
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：130
• 期：Complete
• 页码：28-34
• 全文大小：1345 K
• 卷排序：130

文摘

Alzheimer's disease vaccines were prepared in a soluble or inclusion body system. The inclusion body expression system yielded 40-fold more P particle protein. The soluble expression system produced P particles with better immunogenicity.