Binding analysis of carbon nanoparticles to human immunoglobulin G: Elucidation of the cytotoxicity of CNPs and perturbation of immunoglobulin conformations
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- 作者：Shengrui Zhang Zhangshr09@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Haitao Yang yanghaitaohz@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaohui Ji slgjxh@163.com" class="auth_mail" title="E-mail the corresponding author ; Qin Wang ; qincaimuxu009@sina.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Carbon nanoparticles ; Cytotoxicity ; Human immunoglobulin G ; Interaction ; Spectroscopy
- 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
- 出版年：2016
- 出版时间：5 February 2016
- 年：2016
- 卷：154
- 期：Complete
- 页码：33-41
- 全文大小：1417 K
文摘
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Cytotoxicity and biocompatibility of the CNPs were characterized.
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Binding behavior of CNPs with HIgG was examined by multi-spectroscopic techniques.
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Binding parameters and intermolecular forces between CNPs and HIgG were confirmed.
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Qualitatively conformational changes of HIgG caused by CNPs were determined.