Expression of netrin-1 by hypoxia contributes to the invasion and migration of prostate carcinoma cells by regulating YAP activity
详细信息 查看全文
- 作者：Haiwen Chen ; Qi Chen ; qichenqcf@sina.com" class="auth_mail" title="E-mail the corresponding author ; Qidong Luo
- 关键词：Prostate cancer ; Netrin-1 ; Hypoxia ; Cell invasion ; Cell migration ; YAP
- 刊名：Experimental Cell Research
- 出版年：2016
- 出版时间：10 December 2016
- 年：2016
- 卷：349
- 期：2
- 页码：302-309
- 全文大小：1582 K
文摘
- •
Hypoxia increases the expression of netrin-1 in prostate cancer cells.
- •
Knockdown of netrin-1 inhibits hypoxia-induced invasion, migration and EMT.
- •
Netrin-1 is involved in hypoxia-induced activation of YAP.
- •
Hypoxia-induced YAP activation accounts for DC145 cell invasion and migration.
- •
YAP elevation abates the inhibition of netrin-1 silence on cell metasis upon hypoxia.