Annonaceous acetogenins (ACGs) nanosuspensions based on a self-assembly stabilizer and the significantly improved anti-tumor efficacy
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- 作者：Jingyi Honga ; hongjingyi513@163.com" class="auth_mail" title="E-mail the corresponding author ; Yanhong Lia ; b ; liyanhong936346812@163.com" class="auth_mail" title="E-mail the corresponding author ; Yao Xiaoa ; b ; 18811545437@163.com" class="auth_mail" title="E-mail the corresponding author ; Yijing Lia ; yjli920730@163.com" class="auth_mail" title="E-mail the corresponding author ; Yifei Guoa ; ffguo@163.com" class="auth_mail" title="E-mail the corresponding author ; Haixue Kuangb ; hxkuang56@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiangtao Wanga ; xtaowang@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Annonaceous acetogenins ; Nanosuspensions ; Self-assembly stabilizer ; Cyclodextrin ; Anti-tumor activity
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 September 2016
- 年：2016
- 卷：145
- 期：Complete
- 页码：319-327
- 全文大小：2431 K
文摘
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HP-β-CD and soybean lecithin were self-assembled into a novel stabilizer.
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ACGs were made into nanosuspensions for the first time with a high drug payload.
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ACGs-NSps had significantly enhanced cytotoxicity compared with ACGs solution.
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ACGs-NSps significantly improved ACGs’ antitumor efficacy in vivo.