Esterase D enhances type I interferon signal transduction to suppress foot-and-mouth disease virus replication
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- 作者：Weiwei Li ; Zixiang Zhu ; zhuzixiang@caas.cn" class="auth_mail" title="E-mail the corresponding author ; Weijun Cao ; Fan Yang ; Xiangle Zhang ; Dan Li ; Keshan Zhang ; Pengfei Li ; Ruoqing Mao ; Xiangtao Liu ; Haixue Zheng ; haixuezheng@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Foot-and-mouth disease virus ; Esterase D ; IRF3 ; Interferon-stimulated genes ; Antiviral response
- 刊名：Molecular Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：112-121
- 全文大小：2922 K
文摘
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FMDV infection induces the expression of esterase D (ESD) in PK-15 cells.
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ESD restricts FMDV replication in PK-15 cells.
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ESD enhances IFN-β signal transduction through promoting phosphorylation of IRF3.
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ESD suppresses FMDV replication through upregulation of various interferon-stimulated genes (ISGs).