Hemoglobin A1C is independently associated with severity and prognosis of brainstem infarctions

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• 作者：Haiyan Li^a ; Zhuang Kang^b ; Wei Qiu^a ; Biao Hu^c ; Ai-min Wu^a ; Yongqiang Dai^a ; Xueqiang Hu^a ; Jesse Luo^d ; Bingjun Zhang^a ; Zhengqi Lu^a ; ^{lzq1828@yahoo.com.cn}
• 关键词：Brainstem infarctions ; Hemoglobin A1C ; Prognosis ; Severity
• 刊名：Journal of the Neurological Sciences
• 出版年：2012
• 出版时间：15 June, 2012
• 年：2012
• 卷：317
• 期：1-2
• 页码：87-91
• 全文大小：397 K

文摘

Objective

To assess the association of Hemoglobin A1C (HbA1c) with acute brainstem infarctions (BSIs) and to determine whether HbA1c is an independent risk factor in BSIs patients.

Methods

96 only BSIs patients were categorized into four groups according to HbA1c as < 6 % , ?#xA0;6 % but < 7 % , ?#xA0;7 % but < 8 % , or ?#xA0;8 % , respectively. The association of the four HbA1c groups with diffusion-weighted imaging (DWI) infarct volumes (DIV), National Institutes of Health Stroke Scale (NIHSS), and follow-up modified Rankin Scale (FmRS) scores were analyzed. Patients also were categorized into two groups according to HbA1c < 6 % or ?#xA0;6 % . Logistic regression analyses were performed to determine independent risk factors.

Results

There was a significant correlation between HbA1c and DIV (Spearman ¦Ñ = 0.339, P = 0.001), NIHSS scores (¦Ñ = 0.292, P = 0.004) and FmRS scores (¦Ñ = 0.315, P = 0.002). The incidence of pons infarction was highest in BSIs and patients with HbA1c ?#xA0;6 % showed significantly more frequent isolated pontine infarction. Logistic regression analyses showed that only HbA1c was independently associated with larger DIV (P = 0.025) and FmRS scores (P = 0.026).

Conclusions

These results suggest that elevated HbA1c level may be a potential serologic marker in the evaluation of the severity and prognosis of acute BSIs. There is an urgent need to study control of diabetes mellitus (DM) before and after BSIs.