Comparison of Edwards SAPIEN 3 versus SAPIEN XT in transfemoral transcatheter aortic valve implantation: Difference of valve selection in the real world

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• 作者：Takahide Arai ; MD^a ; Thierry Lefè ; vre ; MD ; FESC ; FSCAI^a ; ^{t.lefevre@angio-icps.com} ; Thomas Hovasse ; MD^a ; Marie-Claude Morice ; MD ; FACC ; FESC^a ; Philippe Garot ; MD^a ; Hakim Benamer ; MD^a ; Thierry Unterseeh ; MD^a ; Kentaro Hayashida ; MD ; PhD ; FESC^a ; ^b ; Yusuke Watanabe ; MD^a ; ^c ; Erik Bouvier ; MD^a ; Bertrand Cormier ; MD^a ; Bernard Chevalier ; MD ; FESC ; FSCAI^a
• 关键词：Severe symptomatic aortic stenosis ; Transcatheter aortic valve implantation ; SAPIEN 3 ; SAPIEN XT
• 刊名：Journal of Cardiology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：69
• 期：3
• 页码：565-569
• 全文大小：473 K
• 卷排序：69

文摘

The SAPIEN 3 (S3; Edwards Lifescience, Irvine, CA, USA) is a new-generation percutaneous aortic valve with better profile, more precise handling and positioning, designed to reduce the risk of post-procedural paravalvular aortic leak (PVL). The aim of this study was to compare the S3 valve and SAPIEN XT valve (SXT).MethodsThe last 89 transfemoral transcatheter aortic valve implantation (TAVI) cases using SXT were compared to the first 111 cases using the S3.ResultsPatient age and logistic EuroSCORE were similar (83.1 years vs 83.0 years and 18.2% vs 16.6%) in the S3 and SXT groups, respectively as were other baseline characteristics. The ratio of valve diameter/calculated annulus average diameter (CAAD) by multi-detector row computed tomography was significantly lower in the S3 group (1.06 vs 1.09, p < 0.001) as was the annular area oversizing percentage (11.3% vs 20.5%, p < 0.001). Furthermore, a smaller valve was selected in S3 cases with borderline CAAD compared to SXT cases. Nevertheless, the frequency of paravalvular aortic leakage (PVL) ≥2 tended to be reduced in the S3 group (5% vs 9%, p = 0.339). The rate of major vascular complications was significantly lower with S3 (3% vs 12%, p = 0.013). In addition, 30-day mortality was significantly lower in the S3 group (0% vs 5%, p = 0.044).ConclusionsAlthough TAVI using S3 tended to be carried out with a less oversized valve compared to TAVI using SXT, the frequency of post-procedural PVL ≥2 tended to be lower in the S3 group. The outcomes including vascular complications and 30-day mortality showed a trend in favor of the S3 group.