Effect of carbogen on tumor oxygenation: combined fluorine-19 and proton MRI measurements

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• 作者：Fan ; Xiaobing ; River ; Jonathan N. ; Zamora ; Marta ; Al-Hallaq ; Hania A. ; Karczmar ; Gregory S.
• 关键词：BOLD effect ; Tumor ; Fluorine-19 ; Carbogen ; Oxygen tension
• 刊名：International Journal of Radiation Oncology*Biology*Physics
• 出版年：2002
• 出版时间：November 15, 2002
• 年：2002
• 卷：54
• 期：4
• 页码：1202-1209
• 全文大小：227 K

文摘

Purpose: Blood oxygen level dependent (BOLD) contrast in magnetic resonance imaging (MRI) has been widely used for noninvasive evaluation of the effects of tumor-oxygenating agents. However, there have been few tests of the validity of this method. The goal of the present work was to use the T₁ of fluorine-19 in perfluorocarbon (PFC) emulsions as a “gold standard” for comparison with BOLD MRI.