In vitro bioacessibility and transport across Caco-2 monolayers of haloacetic acids in drinking water
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- 作者：A. Meloa ; b ; M.A. Fariaa ; mfaria@ff.up.pt" class="auth_mail" title="E-mail the corresponding author ; E. Pintoa ; C. Mansilhab ; c ; I.M.P.L.V.O. Ferreiraa
- 关键词：Bioavailability ; Haloacetic acids ; TCAA ; Tap water ; In vitro digestion ; LC-MS/MS
- 刊名：Chemosphere
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：19-26
- 全文大小：649 K
文摘
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Bioaccessibility and transport in Caco-2 monolayers was assessed for 5 HAAs.
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Monohaloacids (MCAA and MBAA) are not bioaccessible after simulated digestion.
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Dihaloacids (DCAA and DBAA) and trihaloacids (TCAA) are highly bioaccessible (>85%).
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Dihaloacids (DCAA and DBAA) were highly permeable throughout the Caco-2 monolayer.
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TCAA showed no relevant permeability trough Caco-2 monolayers.