The Synthesis of 1-Aminodihydroisoquinolines by an Imine Addition-Cyclisation Reaction

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• 作者：Beaton ; Haydn ; Hamley ; Peter ; Tinker ; Alan C.
• 刊名：Tetrahedron Letters
• 出版年：1998
• 出版时间：March 5, 1998
• 年：1998
• 卷：39
• 期：10
• 页码：1227-1230
• 全文大小：198 K

文摘

A variety of 1-amino-3,4-dihydroisoquinolines substituted at the 3-position and related thienopyridines were prepared by lithiation of ortho-methyl aromatic nitriles, addition to N-trimethylsilylimines and spontaneous cyclisation.