Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction
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- 作者：Nuno Miguel Luis1 ; nuno.luis@univ-amu.fr" class="auth_mail" title="E-mail the corresponding author ; Lifen Wang1 ; Mauricio Ortega1 ; Hansong Deng1 ; Subhash D. Katewa1 ; Patrick Wai-Lun Li1 ; Jason Karpac2 ; Heinrich Jasper1 ; 3 ; hjasper@buckinstitute.org" class="auth_mail" title="E-mail the corresponding author ; Pankaj Kapahi1 ; 4 ; pkapahi@buckinstitute.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：dietary restriction ; aging ; IRE1 ; metabolic adaptation ; lipid turnover ; longevity ; Drosophila
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：25 October 2016
- 年：2016
- 卷：17
- 期：5
- 页码：1207-1216
- 全文大小：1823 K
文摘
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ECs of the Drosophila intestine require IRE1/XBP1 for higher lipid turnover upon DR
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This metabolic adaptation is required for DR-mediated lifespan extension
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The IRE1/XBP1 module regulates lipid turnover by inducing Sugarbabe
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Sugarbabe is required for metabolic adaptation and increased longevity upon DR