- 作者：Andrew S. Hanzlicek ; MS ; DVM<sup>asup><sup> ; sup><sup>andrew.hanzlicek@okstate.edusup> ; Ronette Gehring ; BVSc ; MMedVet ; MRCVS<sup>asup> ; Butch KuKanich ; PhD ; DVM<sup>bsup> ; Kate S. KuKanich ; PhD ; DVM<sup>asup> ; Michele Borgarelli ; PhD ; DVM<sup>asup> ; Nicole Smee ; DVM<sup>asup> ; Emily E. Olson ; DVM<sup>asup> ; Marco Margiocco ; MS ; DVM<sup>asup><sup> ; sup><sup>csup>
- 关键词：Cardiomyopathy ; Heart failure ; Inodilator ; Ionotrope ; Pharmacology
- 刊名：Journal of Veterinary Cardiology
- 出版年：2012
- 出版时间：December, 2012
- 年：2012
- 卷：14
- 期：4
- 页码：489-496
- 全文大小：246 K
ss=""h4"">Objective
To describe the pharmacokinetics of oral pimobendan in healthy cats.ss=""h4"">Animals
18 purpose-bred cats.
ss=""h4"">Methods
In 10 cats, blood samples were collected before, and at multiple time points after, a single oral dose of pimobendan (0.28?¡À?0.04?mg/kg). In 8 cats, blood samples were collected at 3 various time points on the first and third days of twice daily oral dosing of pimobendan for a total of 7 doses (0.31?¡À?0.04?mg/kg). Plasma concentrations of pimobendan were quantified by high pressure liquid chromatography coupled to tandem mass spectrometry.
ss=""h4"">Results
A 1-compartment open model with first order absorption in and elimination from the central compartment with a lag time best describes the disposition of pimobendan. Two cats were removed from final pharmacokinetic descriptive analysis due to delayed minimal absorption from gastrointestinal adverse effects. After a lag time (0.3?¡À?0.06?h), pimobendan was rapidly absorbed (absorption half-life?=?0.2?¡À?0.08?h) and eliminated (elimination half-life?=?1.3?¡À?0.2?h). Maximum plasma concentrations (34.50?¡À?6.59?ng/mL) were high and were predicted 0.9?h after drug administration. Apparent volume of distribution at steady state (per bioavailability) was large (8.2?¡À?2.5?L/kg). The multi-dose study showed the pharmacokinetic model to be robust.
ss=""h4"">Conclusion
When administered a similar dose on a per weight basis, pimobendan has a substantially longer elimination half-life and maximal drug plasma concentration in cats as compared to those previously reported in dogs.