Organocatalytic enantioselective Michael reaction of 1,3-dicarbonyls with α-substituted β-nitroacrylates

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• 作者：Hsuan-Hao Chang^a ; ¹ ; Kai-Ti Chu^b ; ¹ ; Ming-Hsi Chiang^b ; Jeng-Liang Han^a ; ^{jlhan@cycu.edu.tw}
• 关键词：Asymmetric Michael reaction ; 1 ; 3-Dicarbonyls ; α-Substituted-β-nitroacrylates ; Isoxazole ring ; Organocatalysis
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：9 February 2017
• 年：2017
• 卷：73
• 期：6
• 页码：727-734
• 全文大小：819 K
• 卷排序：73

文摘

An efficient asymmetric Michael reaction of 1,3-dicarbonyl compounds with α-Substituted-β-Nitroacrylates has been developed by using a cinchona-thiourea bifunctional organocatalyst in high yields and enantioselectivies. One of adducts could be transformed into a chiral β-nitroester bearing an isoxazole skeleton and an all-carbon quaternary chiral center.