A Two-Step Haploidentical Versus a Two-Step Matched Related Allogeneic Myeloablative Peripheral Blood Stem Cell Transplantation
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- 作者：Sameh Gaballa1 ; samehgaballa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Neil Palmisiano1 ; Onder Alpdogan1 ; Matthew Carabasi1 ; Joanne Filicko-O'Hara1 ; Margaret Kasner1 ; Walter K. Kraft2 ; Benjamin Leiby2 ; Ubaldo Martinez-Outschoorn1 ; William O'Hara3 ; Barbara Pro1 ; Shannon Rudolph1 ; Manish Sharma1 ; John L. Wagner1 ; Mark Weiss1 ; Neal Flomenberg1 ; Dolores Grosso1
- 关键词：Haploidentical ; Matched related ; Myeloablative total body irradiation conditioning ; Peripheral blood stem cell transplantation ; Two-step approach
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：22
- 期：1
- 页码：141-148
- 全文大小：1229 K
文摘
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Peripheral blood stem cell source is feasible in haploidentical transplantation.
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The 2-step approach allows separate control over the graft T cell and stem cell doses.
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Early immune recovery was seen in both haploidentical and matched related groups.
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Clinical outcomes were comparable between haploidentical and matched related groups.
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Grade 2 acute graft-versus-host disease was higher in the haploidentical group.
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