d="p0010">Neutral substituents can replace charged carboxylate groups.
dd><dt class="label">•dt><dd>d="p0015">Crystal structure of amide dFont">12e bound to Kelch domain.
dd><dt class="label">•dt><dd>d="p0020">Unsymmetrically substituted analogs can have high affinity for the Kelch domain.
dd><dt class="label">•dt><dd>d="p0025">Binding site waters can be displaced without incurring a large energetic penalty.
dd>dl>