Allergic cross-reactivity was assessed for three edible mealworm species in vitro.
Mealworm protein cross-reacted with sera from HDM and crustacean allergic patients.
Cross-reactive proteins included tropomyosin, α-amylase and muscle myosin.
Effect of heat processing and in vitro digestion on allergenicity was determined.
Heat processing and in vitro digestion did diminish but not eliminate allergenicity.