The effect of different anesthetics on tumor cytotoxicity by natural killer cells

详细信息    查看全文

• 作者：Kazumasa Tazawa^a ; ^c ; ^{kazumasa.tazawa@childrens.harvard.edu} ; Sophia Koutsogiannaki^a ; ^b ; ^{sophia.koutsogiannaki@childrens.harvard.edu} ; Matthew Chamberlain^a ; ^{matthew.chamberlain@childrens.harvard.edu} ; Koichi Yuki^a ; ^b ; ^{koichi.yuki@childrens.harvard.edu}
• 关键词：Volatile anesthetic ; Tumor recurrence/metastasis ; Natural killer cell ; Leukocyte function-associated antigen-1
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：266
• 期：Complete
• 页码：23-31
• 全文大小：1491 K
• 卷排序：266

文摘

LFA-1 is involved in NK cell-mediated conjugation, polarization and tumor cytotoxicity. Volatile anesthetics isoflurane and sevoflurane are LFA-1 inhibitors. Volatile anesthetics attenuated NK-cell mediated conjugation, polarization and cytotoxicity. Intravenous anesthetics did not affect these NK cell functions.