Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction
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- 作者：Yusuke Onakaa ; b ; 1 ; Norihito Shintani ; Ph.D.a ; 1 ; shintani@phs.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Takanobu Nakazawaa ; c ; d ; 1 ; Takuya Kanoha ; 1 ; Yukio Agoa ; e ; Toshio Matsudae ; Ryota Hashimotof ; g ; Kazutaka Ohig ; Hiroyuki Hiraih ; Kin-ya Nagatah ; Masataka Nakamurai ; Atsushi Kasaia ; Atsuko Hayata-Takanoa ; f ; Kazuki Nagayasua ; c ; Kazuhiro Takumad ; f ; Asao Ogawaj ; Akemichi Babak ; Hitoshi Hashimoto ; Ph.D.a ; c ; f ; l ; hasimoto@phs.osaka-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：CRTH2 ; chemoattractant receptor homologous molecule expressed on T helper type 2 cells ; COX ; cyclooxygenase ; LPS ; lipopolysaccharide ; NMDA ; N-methyl-d-aspartate ; NORT ; novel object recognition test ; PVN ; paraventricular nucleus ; PC/RS ; posterior cingulate/retrosplenial cortex ; PG ; prostaglandin ; SNP ; single nucleotide polymorphism ; PFC ; prefrontal cortex
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：314
- 期：Complete
- 页码：77-86
- 全文大小：1254 K
文摘
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Genetic deletion of CRTH2 suppressed MK-801-induced cognitive dysfunction.
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Inhibition of CRTH2 by ramatroban suppressed MK-801-induced cognitive dysfunction.
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Inhibition of COX-1 by SC-560 suppressed MK-801-induced cognitive dysfunction.
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MK-801-induced increase in c-Fos expression in the PVN was abolished in CRTH2−/− mice.
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PGD2-CRTH2 signaling is involved in MK-801-induced cognitive dysfunction.