Designed composites for mimicking compressive mechanical properties of articular cartilage matrix
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- 作者：Youjia Zhua ; 1 ; Hua Wub ; 1 ; Shaofa Sunc ; sunshaofa@mail.hbust.com.cn" class="auth_mail ; Ting Zhoud ; Jingjing Wud ; Ying Wand ; ying_x_wan@yahoo.ca" class="auth_mail
- 关键词：Composite ; Porous scaffold ; Stratiform structure ; Compressive mechanical property ; Articular cartilage matrix
- 刊名：Journal of the Mechanical Behavior of Biomedical Materials
- 出版年：August 2014
- 年：2014
- 卷：36
- 期：Complete
- 页码：32-46
- 全文大小：3480 K
文摘
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Collagen, chitosan copolymer and chondroitin sulfate are used to prepare composites.
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Composites are processed into stratified porous scaffolds for articular cartilage repair.
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Scaffolds are crosslinked using selected crosslinker under optimized conditions.
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Wet-state compressive strength of scaffolds is comparative to that of cartilage matrix.
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Gradient-varied compressive modulus and swelling index for scaffolds are achieved.