Histone deacetylase 1 (HDAC1) regulates retinal development through a PAX6-dependent pathway

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• 作者：Chul-Hong Kim ; Mi-Jin An ; Dae-Hyun Kim ; Jung-Woong Kim ; ^{jungkim@cau.ac.kr}
• 关键词：PAX6 ; HDAC1 ; Protein-protein interaction ; Transcriptional regulation ; Retina ; Development
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：735-741
• 全文大小：992 K
• 卷排序：482

文摘

PAX6 physically interacts with HDAC1 during mouse retina development. HDAC1 represses the transcriptional activity of PAX6. Protein interaction between PAX6 and HDAC1 is required for the selective expression of PAX6 target genes.