Histone deacetylases (HDAC) in physiological and pathological bone remodelling

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• 作者：M.D. Cantley^a ; ^b ; ^c ; ¹ ; ^{melissa.cantley@adelaide.edu.au} ; A.C.W. Zannettino^a ; ^b ; P.M. Bartold^c ; D.P. Fairlie^d ; ^e ; D.R. Haynes^f
• 关键词：Histone deacetylases (HDAC) ; Osteoclasts ; Osteoblasts ; Periodontitis ; Rheumatoid arthritis ; Myeloma bone disease
• 刊名：Bone
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：95
• 期：Complete
• 页码：162-174
• 全文大小：421 K
• 卷排序：95

文摘

HDACi can regulate bone remodelling by suppressing osteoclasts and promoting osteoblasts HDAC isozymes have differing roles in differentiation and function of bone cells, osteoclasts, osteoblasts and osteocytes. Novel isozyme-specific HDACi are critical to elucidate HDAC roles in bone remodelling and communication between bone cells. For non-malignancies, such inflammatory arthritis, HDACi can be more beneficial in vivo at much lower doses.