Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems
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- 作者：Evan Murray1 ; 2 ; 10 ; Jae Hun Cho3 ; 10 ; Daniel Goodwin5 ; 10 ; Taeyun Ku2 ; 4 ; 10 ; Justin Swaney3 ; 10 ; Sung-Yon Kim2 ; Heejin Choi2 ; 4 ; Young-Gyun Park2 ; 4 ; Jeong-Yoon Park2 ; 4 ; Austin Hubbert3 ; Margaret McCue1 ; 4 ; Sara Vassallo2 ; 4 ; Naveed Bakh3 ; Matthew P. Frosch6 ; Van J. Wedeen7 ; H. Sebastian Seung5 ; 8 ; Kwanghun Chung1 ; 2 ; 3 ; 4 ; 9 ; khchung@mit.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2015
- 出版时间：3 December 2015
- 年：2015
- 卷：163
- 期：6
- 页码：1500-1514
- 全文大小：8417 K
文摘
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SWITCH controls chemical reaction kinetics for uniform, scalable tissue processing
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SWITCH enables multiple rounds (> 20) of relabeling for multiplexed imaging
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SWITCH is a fast, cost-effective, and easy-to-implement tissue-processing framework
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Combinatorial protein expression profiling of the human visual cortex is demonstrated