Liver Function Assessment Using Parenchyma-Specific Contrast-Enhanced Ultrasonography

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• 作者：Jaehyung Park^&lowast ; ; Jinhan Cho^&lowast ; ; ^{jojini@dau.ac.kr" class="auth_mail" title="E-mail the corresponding author} ; Heejin Kwon^&lowast ; ; Myongjin Kang^&lowast ; ; Sangyun Lee^&lowast ; ; Young-hoon Roh^&dagger ; ; Kwan Woo Kim^&dagger ; ; Sung Wook Lee^&Dagger ;
• 关键词：Microbubble contrast agent ; Contrast-enhanced ultrasonography ; Liver cirrhosis ; Liver function ; Sonazoid ; Indocyanine green
• 刊名：Ultrasound in Medicine & Biology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：42
• 期：2
• 页码：430-437
• 全文大小：794 K

文摘

The aim of this study was to assess hepatic functional reserve by analyzing the hepatic parenchyma enhancement curve of parenchyma-specific contrast-enhanced ultrasonography (CEUS). Fifty-two patients with cirrhosis who underwent CEUS and indocyanine green tests (ICG) because of a focal liver lesion were enrolled. We evaluated the hemodynamic-related parameters of the time-intensity curve and compared these findings with the ICG retention rate at 15 min (ICG R15). The correlation between the time from peak to one half (s) and ICG R15 was statistically significant and was relatively proportional to the ICG R15. A cut-off value of 149 s was determined for the time from peak to one half for abnormal ICG R15 (>14). The sensitivity and specificity were 85.7% and 92.3%, respectively, for the detection of abnormal ICG R15. In conclusion, the time from peak to one half of the time-intensity curve of parenchyma-specific CEUS of the liver can be a useful parameter to predict the hepatic reserve in liver cirrhosis.