A scavenger peptide prevents methylglyoxal induced pain in mice

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• 作者：Sebastian Brings^a ; ^b ; ^{sebastian.brings@med.uni-heidelberg.de} ; Thomas Fleming^a ; ^c ; Svenja De Buhr^b ; Barbro Beijer^b ; Thomas Lindner^b ; Artjom Wischnjow^b ; Zoltan Kender^e ; Verena Peters^f ; Stefan Kopf^a ; Uwe Haberkorn^b ; Walter Mier^b ; Peter P. Nawroth^a ; ^c ; ^d
• 关键词：Methylglyoxal ; Scavenger ; Peptide ; Pain ; Diabetic complications
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：1863
• 期：3
• 页码：654-662
• 全文大小：910 K
• 卷排序：1863

文摘

A peptide based MG scavenger with excellent pharmacokinetic properties was developed. The scavenging efficacy and the molecular mechanism of action were demonstrated in vivo. The toxic metabolite MG was excreted upon binding to the scavenger.