Palladium-benzodiazepine derivatives as promising metallodrugs for the development of antiepileptic therapies
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- 作者：Walleska Bismaida Zacarias Galvã ; o Barrosa ; walleska_bismaida@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Allysson Haide Queiroz da Silvaa ; allyssonhaide@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Ana Soraya Lima Barbosaa ; c ; anasoraya.farma@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Á ; bner Magalhã ; es Nunesa ; magalhaes.abner@gmail.com" class="auth_mail" title="E-mail the corresponding author ; José ; Rui Machado Reysa ; trapima@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Heitor Gomes de Araú ; jo-Filhob ; heitorgaf@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jullyana de Souza Siqueira Quintansb ; jullyanas@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Lucindo José ; Quintans-Jú ; niorb ; lucindojr@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Michel Pfefferc ; pfeffer@unistra.fr" class="auth_mail" title="E-mail the corresponding author ; Valé ; ria Rodrigues dos Santos Maltad ; vrsm@qui.ufal.br" class="auth_mail" title="E-mail the corresponding author ; Mario Roberto Meneghettia ; mrm@qui.ufal.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Palladacycles ; Diazepam ; Benzodiazepine ; Convulsion ; Epilepsy
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：155
- 期：Complete
- 页码：129-135
- 全文大小：606 K
文摘
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Diazepam-palladacycles were prepared by C-H activation of diazepam with palladium salts.
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Palladacycles[(DZP)PdCl]2 and[(DZP)PdOAc]2 display significant anticonvulsant action.
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The antiepileptic potential of the complexes were assessed via the two animal models.
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Two promising prototypes of metallodrugs to treat patients with epilepsy were prepared.