Characterization of the surface geometry of acetyl-[Leu^28,31]-NPY(24-36), a selective Y₂ receptor agonist, onto the Ag and Au surfaces

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• 作者：Helena Domin^a ; Dominika Święch^b ; Natalia Piergies^c ; Ewa Pięta^d ; Younkyoo Kim^e ; Edyta Proniewicz^b ; ^{proniewi@agh.edu.pl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Surface-enhanced Raman spectroscopy ; SERS ; Ag and Au surfaces ; Mutated C-terminal analogue of NPY ; Y2 receptor agonist
• 刊名：Vibrational Spectroscopy
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：85
• 期：Complete
• 页码：1-6
• 全文大小：1128 K

文摘

In this study, we present adsorption geometry of the mutated C-terminal analogue of neuropeptide Y (NPY), acetyl-[Leu^28,31]-NPY(24-36), immobilized onto different SERS-active substrates (colloidal and specifically prepared in oxidation-reduction cycles Ag and Au substrates). Some changes in the adsorption geometry of the investigated peptide immobilized onto these SERS-active substrates are observed. The obtained SERS results demonstrated that the Tyr and Arg residues are mainly responsible for the molecule/metal interaction onto the Ag and Au surfaces.