Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality
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- 作者：Xiao Yu1 ; 3 ; 8 ; Baowei Cai3 ; 4 ; 8 ; Mingjun Wang2 ; 3 ; Peng Tan3 ; 7 ; Xilai Ding3 ; Jian Wu5 ; Jian Li4 ; Qingtian Li3 ; Pinghua Liu3 ; Changsheng Xing3 ; Helen Y. Wang3 ; Xin-zhuan Su4 ; 5 ; xsu@niaid.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Rong-Fu Wang3 ; 6 ; 7 ; 9 ; rwang3@houstonmethodist.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Type I IFN signaling ; Innate immune response ; Plasmacytoid dendritic cells ; Malaria infection
- 刊名：Immunity
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：45
- 期：5
- 页码：1093-1107
- 全文大小：5703 K
文摘
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cGAS functions as a DNA sensor in vivo for detecting malaria genomic DNA
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STING- and MAVS-mediated signaling induces a negative regulator SOCS1 expression
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SOCS1 inhibits MyD88-mediated type I IFN signaling in pDCs
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Type I IFN produced by pDCs activates cDCs and macrophages for adaptive immunity